Antidiuretic hormone (ADH) controls the amount of water reabsorbed by the kidneys. ADH is made in the hypothalamus of the brain. The pituitary gland, at the base of the brain, stores and releases ADH.
Central DI occurs when the hypothalamus does not make enough ADH.
NDI occurs when the kidneys do not respond to ADH.
Some diabetes insipidus is caused by genetic problems. Most others develop after an injury, illness, or exposure to a medication.
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Factors that may increase your risk of DI include:
Central diabetes insipidus (central DI)
- Damage to the hypothalamus or pituitary glands due to surgery, infection, stroke, brain tumor, or head injury
- Certain conditions that can infiltrate the brain, such as sarcoidosis, tuberculosis, lymphocytic hypophysitis, and granulomatosis with polyangiitis
- Most idiopathic or congenital causes result in central DI
- Nephrogenic diabetes insipidus (NDI)
- Certain medications, such as lithium—the most common cause of NDI
- Kidney disease such as polycystic kidney disease
- Kidney infection or blockage
- Protein malnutrition
- Certain conditions such as hypercalcemia, hypokalemia, sarcoidosis, amyloidosis, and sickle cell disease
You will be asked about your symptoms and medical history. A physical exam may be done.
Your bodily fluids may be tested. This can be done with:
- Blood tests
- Urine tests
- Water deprivation test
- Desmopressin challenge test
Images may be taken of your bodily structures, usually the urinary tract or brain. This can be done with ultrasound or an MRI scan.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Edits to original content made by Denver Health.
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American Diabetes Association http://www.diabetes.org
Nephrogenic Diabetes Insipidus Foundation http://www.ndif.org
Canadian Diabetes Association http://www.diabetes.ca
Health Canada http://www.hc-sc.gc.ca
Central diabetes insipidus. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T115774/Central-diabetes-insipidus . Updated June 7, 2017. Accessed August 24, 2017.
Diabetes insipidus. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: https://www.niddk.nih.gov/health-information/kidney-disease/diabetes-insipidus. Updated January 13, 2014. Accessed August 24, 2017.
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Nephrogenic diabetes insipidus. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116727/Nephrogenic-diabetes-insipidus . Updated June 7, 2017. Accessed August 24, 2017.
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