Prolonged or excess exposure to cortisol may be caused by:
- Long-term use of corticosteroid hormones, such as cortisone or prednisone
Excess production of cortisol by:
- Tumor or abnormality of the adrenal gland.
- Tumor or abnormality of the pituitary gland. In the case of a pituitary tumor , it is called Cushing disease
- Rarely, tumors of the lung , thyroid , kidney , pancreas , or thymus gland.
|Pituitary and Adrenal Glands|
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Cushing syndrome may cause:
- Weight gain of the upper body and trunk
- Rounded face
- Severe fatigue or muscle weakness
- Easily bruised, thinner skin
- Purple stretch marks
- Excess hair growth or acne in women
- Menstrual disorders, especially infrequent or absent periods
- Reduced fertility and interest in sex
- Personality changes or mood swings
- Bone loss— osteoporosis
You will be asked about your symptoms and medical history. A physical exam will be done. Tests may be done to determine the level of cortisol and find a cause.
Blood tests, urine tests, and saliva tests may be done.
Imaging tests evaluate the pituitary and adrenal glands, and other internal structures. These may include:
- MRI scan
- CT scan
- Chest x-ray
- Bone density test
Treatment of Cushing syndrome depends on the cause. Talk with your doctor about the best treatment plan for you. Options include:
- Gradual withdrawal of cortisone-type drugs under close medical supervision
- Surgical removal of tumor
- Surgical removal of part, all, or both adrenal glands
- Radiation therapy for some persistent tumors
- Drugs that decrease cortisol production or block the functioning of other adrenal products
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
Edits to original content made by Denver Health.
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a (Cushing Disease; Hypercortisolism)
Cushing's Support and Research Foundation http://www.CSRF.net
Family Doctor—American Academy of Family Physicians http://familydoctor.org
Health Canada https://www.canada.ca
The College of Family Physicians of Canada http://www.cfpc.ca
Arnaldi G, Angeli A, Atkinson AB, et al. Diagnosis and complications of Cushing’s syndrome: a consensus statement. J Clin Endocrinolo Metabo. 2003;88(12):5593-5602.
Cushing disease. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T127665/Cushing-disease . Updated June 15, 2017. Accessed March 5, 2018.
Cushing's syndrome. National Institute of Diabetes and Digestive and Kidney Disorders website. Available at: http://www.niddk.nih.gov/health-information/health-topics/endocrine/cushings-syndrome/Pages/fact-sheet.aspx. Updated April 2012. Accessed March 5, 2018.
Diez JJ, Iglesias P. Pharmacological therapy of Cushing’s syndrome: drugs and indications. Mini Rev Med Chem. 2007;7(5):467-480.
Kirk LF Jr, Hash RB, Katner HP, Jones T. Cushing's disease: clinical manifestations and diagnostic evaluation. Am Fam Physician. 2000;62(5):1119-1127.
Tritos NA, Biller BM, Swearingen B. Management of Cushing disease. Nat Rev Endocrinol. 2011;7(5):279-289.
Makras P, Toloumis G, Papadogias D, Kaltsas GA, Besser M. The diagnosis and differential diagnosis of endogenous Cushing’s syndrome. Hormones. 2006;5(4):231-250.